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Tissue-resident memory-like T cells in tumor immunity: Clinical implications
Madhav V Dhodapkar1, Kavita M Dhodapkar2
1Department of Hematology / Medical Oncology, Emory University, Atlanta, GA, United States; Winship Cancer Institute, Emory University, Atlanta, GA, United States.
Seminars in Immunology
|October 4, 2020
Summary
Tissue-resident memory (TRM) T cells are crucial for regional immunity and anti-tumor responses. Understanding TRM biology can improve cancer immunotherapies like vaccines and checkpoint blockade.
Area of Science:
- Immunology
- Oncology
- Cell Biology
Background:
- Tissue-resident memory (TRM) T cells are non-circulating lymphocytes integral to regional immunity.
- TRM-like cells are found in human tumors, correlating with patient outcomes and immunotherapy response.
- TRM cells demonstrate anti-tumor immunity in preclinical models.
Purpose of the Study:
- To review recent advancements in TRM T cell biology.
- To explore the implications of TRM biology for cancer immunotherapy.
- To discuss how TRM insights can address tumor immune microenvironment heterogeneity.
Main Methods:
- Review of current literature on TRM cell biology.
- Analysis of TRM cell presence in human tumors.
- Examination of TRM cell function in murine anti-tumor models.
Main Results:
- TRM cells are key players in anti-tumor immunity.
- TRM cell presence is linked to improved outcomes in cancer patients.
- TRM biology offers potential for enhancing cancer treatments.
Conclusions:
- New insights into TRM T cell biology have significant clinical implications.
- Understanding TRM cells can help overcome challenges in cancer immunotherapy.
- Targeting TRM cells may improve the efficacy of cancer vaccines, immune-checkpoint blockade, and adoptive cellular therapies.
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