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Updated: Dec 6, 2025
Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia
Published on: January 27, 2018
Coagulation status in patients with alopecia areata: a cross-sectional study
Safoura Shakoei1, Maryam Ghiasi2, Kataun Ziaee3
1Department of Dermatology, Imam Khomeini Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran - dr.shakoei@gmail.com.
Background:
Alopecia areata (AA) is an autoimmune skin disease that causes non-scarring hair loss with lymphatic infiltration around and within follicles. There are interactions between inflammation and coagulation. The present study investigated the changes in coagulation status in patients with AA.
Methods:
In this study, the plasma level of three coagulation markers including fibrinogen, C-reactive protein (CRP), and D-dimer were measured in 30 patients (21 females 9 male) and 30 controls (21 females 9 male) matched by age and sex, and the results were compared between groups.
Results:
Plasma D-dimer levels were significantly higher in patients with AA (398.45±300 ng/mL vs. 244.4±129.92 ng/mL, P=0.014). Plasma fibrinogen and CRP levels were not significantly different between the two groups. There was no correlation between the plasma levels of the studied coagulation markers and the severity/duration of the disease, sex, and age.
Conclusions:
As the present study was the first investigation on the coagulation status in patients with AA, elevated D-dimer levels in alopecia areata may suggest a deficient coagulation in these patients that may contribute to an increase in the risk of thrombosis. Further studies are needed to evaluate this hypothesis using a larger sample size.
