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Information-Driven Design as a Potential Approach for 3D Printing of Skeletal Muscle Biomimetic Scaffolds
Silvia Baiguera1,2,3, Costantino Del Gaudio4, Felicia Carotenuto1,2,3
1Departmet of Fusion and Technologies for Nuclear Safety and Security, Diagnostic and Metrology (FSN-TECFIS-DIM), ENEA, 00196 Roma, Italy.
Nanomaterials (Basel, Switzerland)
|October 14, 2020
Summary
Severe muscle injuries require advanced treatments. This study explores using decellularized extracellular matrix (ECM) to create 3D scaffolds for skeletal muscle tissue engineering and guided healing.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Severe muscle injuries present significant clinical challenges.
- Current tissue engineering solutions for muscle repair are insufficient.
- Biomimetic approaches are needed for effective muscle regeneration.
Purpose of the Study:
- To explore the use of decellularized extracellular matrix (ECM) for skeletal muscle tissue engineering.
- To develop bioactive and biomimetic 3D scaffolds for guided muscle healing.
- To leverage ECM's inherent properties for neomyogenesis and vascularization.
Main Methods:
- Systematic review of biomaterials and scaffold manufacturing findings.
- Processing and 3D printing of skeletal muscle decellularized ECM (e.g., via stereolithography).
- Incorporation of biochemical and topographical cues into scaffolds.
Main Results:
- Decellularized ECM can be fabricated into 3D scaffolds.
- These scaffolds possess bioactive and biomimetic properties.
- Scaffolds can be tailored for skeletal muscle regenerative applications.
Conclusions:
- Skeletal muscle decellularized ECM is a promising biomaterial for tissue engineering.
- 3D printed ECM scaffolds offer a pathway for guided muscle healing.
- This approach holds potential for addressing severe muscle injuries.
