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Related Experiment Video

Updated: Jan 28, 2026

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance

Published on: September 26, 2017

Organ-on-a-Chip and Lab-on-a-Chip Technologies in Cardiac Tissue Engineering.

Daniele Marazzi¹, Federica Trovalusci², Paolo Di Nardo³

¹Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.

Biomimetics (Basel, Switzerland)

|January 27, 2026

Summary

This summary is machine-generated.

Microfluidic technologies like Organ-on-a-Chip and Lab-on-a-Chip create advanced 3D cardiac models. These platforms accelerate cardiovascular research and therapeutic innovation for precision medicine.

Keywords:

Lab-on-a-Chip Organ-on-a-Chip additive manufacturing elastomers heart on a chip

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Last Updated: Jan 28, 2026

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance

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Published on: September 26, 2017

Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip

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Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

Area of Science:

Biomedical Engineering
Cardiovascular Research
Microfluidics

Background:

Traditional 2D cell cultures lack predictive power for cardiac applications.
Microfluidic devices offer advanced biomimicry for in vitro cardiac models.

Purpose of the Study:

To review microfluidic platforms (Organ-on-a-Chip and Lab-on-a-Chip) for cardiac tissue engineering.
To highlight their role in advancing cardiovascular research and precision medicine.

Main Methods:

Organ-on-a-Chip (OoC) and Heart-on-a-Chip systems utilize iPSC-CMs, engineered ECMs, and dynamic stimulation.
Lab-on-a-Chip (LoC) platforms enable miniaturization, integration, and high-throughput analysis.
Multi-organ systems simulate complex physiological interactions.

Main Results:

Microfluidic platforms recreate 3D cardiac microenvironments and dynamic fluid flow.
They facilitate high-throughput screening, cardiotoxicity assessment, and pharmacological testing.
Progress in multi-organ systems allows simulation of heart-organ interactions.

Conclusions:

Microfluidic technologies are strategic tools for cardiovascular research translation.
These platforms accelerate therapeutic innovation and precision medicine approaches.
Challenges include cell immaturity, standardization, and scalability.