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ACE2 mouse models: a toolbox for cardiovascular and pulmonary research
Hongpeng Jia1, Xinping Yue2, Eric Lazartigues3,4,5
1Division of Pediatric Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Nature Communications
|October 15, 2020
Summary
Researchers can use various mouse models to study Angiotensin-converting enzyme 2 (ACE2), a key factor in COVID-19. These models help investigate ACE2
Area of Science:
- Biochemistry
- Virology
- Genetics
Background:
- Angiotensin-converting enzyme 2 (ACE2) is the primary host receptor for SARS-CoV-2, the virus causing COVID-19.
- ACE2 plays a crucial role in regulating the renin-angiotensin system.
- ACE2 exhibits protective functions in cardiovascular, pulmonary, and metabolic diseases.
Purpose of the Study:
- To review existing murine models for ACE2 research.
- To provide researchers with genetic tools for studying ACE2 biology.
- To facilitate investigation into ACE2's role in COVID-19 pathogenesis and treatment.
Main Methods:
- Systematic review of literature on murine models.
- Categorization of models based on ACE2 genetic manipulation (deletion or overexpression).
- Inclusion of models with systemic or organ-specific ACE2 alterations.
Main Results:
- Summary of available murine models with modified ACE2 expression.
- Detailed description of genetic tools for ACE2 research.
- Identification of models relevant to COVID-19 research.
Conclusions:
- A comprehensive overview of ACE2 murine models is presented.
- These genetic tools are vital for advancing ACE2 research.
- Understanding ACE2 is critical for developing COVID-19 therapies.
