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An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
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Morbidity and Mortality of Large-Vessel Vasculitides

Matthew J Koster1, Kenneth J Warrington2, Eric L Matteson2

  • 1Department of Internal Medicine, Division of Rheumatology, Mayo Clinic College of Medicine and Science, 200 1st Street SW, Rochester, MN, 55905, USA. koster.matthew@mayo.edu.

Current Rheumatology Reports
|October 17, 2020
PubMed

Insights

Giant cell arteritis (GCA) and Takayasu arteritis (TAK) are large-vessel vasculitides causing serious complications. This review details their manifestations and impact on patient survival.

Area of Science:

  • Vascular Medicine
  • Rheumatology
  • Immunology

Background:

  • Giant cell arteritis (GCA) and Takayasu arteritis (TAK) are primary systemic large-vessel vasculitides.
  • These conditions can lead to arterial stenosis, occlusion, aneurysm, and dissection, resulting in severe disease-related consequences.

Purpose of the Study:

  • To review disease-related manifestations of GCA and TAK.
  • To emphasize the impact of these findings on long-term morbidity and mortality.

Main Methods:

  • Literature review of recent findings on GCA and TAK.
  • Focus on clinical manifestations and outcomes.

Main Results:

  • Vision loss is a major morbidity in GCA; aortic disease is recognizable via imaging but requires further guideline development.
  • TAK is a severe, early-onset disease with high morbidity from aortic, pulmonary, cardiovascular, and neurologic involvement.
  • GCA patients have similar mortality to comparators, while TAK patients face notably higher mortality.

Conclusions:

  • A multidisciplinary approach involving expert subspecialists is crucial for managing GCA and TAK.
  • Effective surveillance, identification, and treatment of multi-faceted comorbidities are essential for improving patient outcomes.
Abstract

Keywords:
Giant cell arteritisLarge-vessel vasculitisMorbidityMortalityOutcomeTakayasu arteritis

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