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Oh, the Frustration of Antibodies!

Michael S Kinch1

  • 1Head, Centers for Research Innovation in Biotechnology (CRIB) and Drug Discovery (CDD), Washington University in St. Louis St. Louis, Missouri 63110, United States.

ACS Pharmacology & Translational Science
|October 19, 2020
PubMed

The COVID-19 pandemic has been humbling for the biomedical community, pointing out as much about what we do not know as what we do. Among these learnings are lessons about immune-based measures to prevent or treat a new biothreat. This article summarizes lessons learned from two experimental approaches for passive immunity, convalescent plasma and monoclonal antibody therapy. Two early reports of outcomes, both of which appeared within hours of one another, reveal the importance of blending past learning with a forward-looking approach. These also present cautionary lessons as the world looks to new vaccines to help eradicate this deadly scourge.

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