Related Experiment Video
Updated: Dec 5, 2025

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
Published on: March 14, 2025
Treatment of Necrotizing Soft Tissue Infections: Antibiotics
Oddvar Oppegaard1, Eivind Rath2
1Department of Medicine, Haukeland University Hospital, Bergen, Norway. Oddvar.oppegaard@helse-bergen.no.
Abstract:
Necrotizing soft tissue infections (NSTIs) are severe, life-threatening infections, and early therapeutic intervention is essential. Prompt administration of potent antimicrobial agents is pivotal, but inadequate empirical therapy is unfortunately common. Optimization of the antibiotic treatment strategy in NSTIs requires consideration of local epidemiology of causative pathogens and antimicrobial resistance patterns, knowledge on common pathogenetic mechanisms in NSTIs, and adaptations to pharmacokinetic and pharmacodynamic physiological changes in critically ill patients. In the present article we address all these issues, as well as review and compare contemporary guidelines for antimicrobial treatment of NSTIs from around the world.
Related Concept Videos
Acute Pyelonephritis II: Diagnostic Studies and Management
Endocarditis III: Medical Management
Endocarditis IV: Nursing Management
Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Tonsillitis II: Management
Hand hygiene
Hand washing...
