Effect of Hydrogen Sulfide on Deformability of Rat Erythrocytes

The influence of a hydrogen sulfide donor NaHS (2×10^-5-10^-3 M) on the rat erythrocyte deformability was analyzed by laser diffractometry. NaHS (6×10^-5 M) increased, while NaHS (10^-3 M) reduced erythrocyte deformability. The effect of NaHS (6×10^-5 M) was similar to that of NO donor sodium nitroprusside (SNP, 10^-7 M). However, simultaneous use of NaHS (6×10^-5 M) and SNP induced less pronounced changes in erythrocyte deformability than their individual application. It is likely H₂S, similar to NO, is involved in the regulation of erythrocyte deformability in the microvascular bed.