Related Experiment Video
Updated: Dec 4, 2025
10:52
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
11.5K
Systemic Amyloidosis due to Low-Grade Lymphoma
Ashutosh D Wechalekar1, Raj Chakraborty2, Suzanne Lentzsch2
1National Amyloidosis Centre, University College London (Royal Free Campus), Rowland Hill Street, London NW3 2PF, UK.
Hematology/Oncology Clinics of North America
|October 25, 2020
Summary
Lymphoma-related amyloidosis, a rare condition, typically stems from plasma cell disorders producing specific proteins. Optimal treatment strategies are challenging due to limited clinical trial data, relying on retrospective and small prospective studies.
Area of Science:
- Hematology
- Oncology
- Nephrology
Background:
- Lymphoma-related amyloidosis is a rare clinical entity.
- Systemic light-chain (AL) amyloidosis is often associated with an underlying plasma cell clone.
- This clone produces intact monoclonal immunoglobulin G (IgG) or immunoglobulin A (IgA) proteins.
Purpose of the Study:
- To review and discuss treatment recommendations for lymphoma-related amyloidosis.
- To address the challenges in establishing optimal treatment due to the rarity of the condition.
Main Methods:
- The study is based on a review of existing literature.
- Treatment recommendations are derived from retrospective analyses.
- Data from small, single-center prospective trials were also considered.
Main Results:
- Limited clinical trial data exists for lymphoma-related amyloidosis.
- Optimal treatment determination is hindered by the condition's rarity.
- Current recommendations are based on lower-level evidence.
Conclusions:
- Lymphoma-related amyloidosis requires careful management strategies.
- Treatment decisions rely on retrospective and limited prospective data.
- Further research is needed to establish evidence-based guidelines.
More Related Videos
Related Concept Videos
01:15Secondary Lymphoid Organs
8.4K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
8.4K
01:16Primary Lymphoid Organs
13.7K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
13.7K
03:03Amyloid Fibrils
11.4K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
11.4K
03:03Amyloid Fibrils
6.1K
6.1K
01:18Lymphoid Cells and Tissues
2.4K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
2.4K
01:24Nephrotic Syndrome I : Introduction
304
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
304