COVID-19 in Patients Undergoing Hemodialysis: Prevalence and Asymptomatic Screening During a Period of High Community Prevalence in a Large Paris Center
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Published on: March 14, 2017
Caroline Creput1, Christine Fumeron1, Daniel Toledano1
1Nephrology and Hemodialysis Unit, Diaverum, Paris, France.
Insights
Maintenance hemodialysis patients with COVID-19 had a high risk of hospitalization and death. Universal testing and early diagnosis using lymphopenia and C-reactive protein levels are crucial for managing coronavirus disease 2019 in dialysis centers.
Area of Science:
- Nephrology
- Infectious Diseases
- Epidemiology
Background:
- Patients undergoing maintenance hemodialysis (MHD) have a poor prognosis with coronavirus disease 2019 (COVID-19) due to comorbidities.
- Hemodialysis centers are high-risk environments for COVID-19 transmission during an epidemic.
Purpose of the Study:
- To describe the experience with COVID-19 in 200 MHD patients at a single dialysis center.
- To evaluate the clinical course and outcomes of COVID-19 in this vulnerable population.
Main Methods:
- A descriptive observational cohort study was conducted.
- Included 200 MHD patients, with 38 diagnosed with COVID-19.
- Data collected on diagnosis, clinical course, testing, and outcomes.
Main Results:
- 19% of MHD patients (38/200) were diagnosed with COVID-19.
- 39.5% of COVID-19 patients required hospitalization, with 4 needing ICU care.
- The mortality rate was 21% (8/38), with fever being the most common symptom.
Conclusions:
- MHD patients are highly susceptible to COVID-19, and dialysis centers pose a significant risk.
- Unexplained lymphopenia and elevated C-reactive protein levels suggest COVID-19 in dialysis patients.
- Universal reverse transcriptase-polymerase chain reaction testing and enhanced infection control are recommended.
Rationale & Objective:
Due to extensive comorbid conditions, coronavirus disease 2019 (COVID-19) has a poor prognosis in people receiving maintenance hemodialysis. In this article, we describe our experience with 200 maintenance hemodialysis patients in a hemodialysis center that used universal reverse transcriptase-polymerase chain reaction testing, including 38 COVID-19-positive patients.
Study Design:
Descriptive observational cohort, including the time line of patient diagnoses along with contextual events including precautions, testing, screening algorithms, clinical diagnostics and therapy, and the clinical course of COVID-19-infected patients and their final outcomes.
Setting & Participants:
200 patients within a single hemodialysis center with 2 dialysis clinics in Paris.
Results:
Among 200 maintenance hemodialysis patients, 38 (19%) had COVID-19 diagnosed; of these, 15 (39.5%) were admitted to the hospital, including 4 who required intensive care unit (ICU) care. There were 8 (21%) deaths. The most common symptom was fever, followed by dry cough, fatigue, and dyspnea. All COVID-19-infected patients had lymphopenia and an increase in C-reactive protein levels. Median time from the onset of respiratory symptoms to ICU admission was 1 to 2 days. Durations of non-ICU hospitalizations and ICU stays were 7 and 13 days, respectively.
Limitations:
Retrospective study, single hemodialysis center.
Conclusions:
Dialysis patients are a highly susceptible population and hemodialysis centers are a high-risk area in a COVID-19 epidemic. "Unexplained" lymphopenia and/or an increase in C-reactive protein level should lead physicians to the diagnosis of COVID-19 and should, when possible, be followed by diagnostic testing with universal reverse transcriptase-polymerase chain reaction, as well as the reinforcement of contamination barrier measures.
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