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Updated: Dec 3, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Antimicrobial Stewardship: What the Clinical Laboratory Needs to Know
Diana Alame1, Bryan Hess2, Claudine El-Beyrouty3
1Clinical Microbiology, Thomas Jefferson University Hospital, Anatomy and Cell Biology, Sidney Kimmel Medical College at Thomas Jefferson University, 117 South 11th Street, Pavilion Building, Suite 207, Philadelphia, PA 19107-4998, USA.
Abstract:
Misuse of antibiotics, including unnecessary use or inappropriate selection, may result in side effects and poor outcome in individual patients, as well as contribute to the spread of antimicrobial resistance. Antimicrobial stewardship programs exist to reduce such misuse of antibiotics and ill effect in order to promote patient outcome. The importance of diagnostics, antibiogram data, possible interventions, and impact are reviewed. It is essential for clinical microbiologists and other health care members to understand the field and scope of antimicrobial stewardship, actively participate in, and understand the value they bring to supporting their institution's efforts.
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