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Purinergic Signaling Within the Tumor Microenvironment
Dobrin Draganov1, Peter P Lee2
1Calidi Biotherapeutics, San Diego, CA, USA.
Advances in Experimental Medicine and Biology
|October 30, 2020
Summary
Extracellular ATP (eATP) is abundant in the tumor microenvironment (TME), influencing cancer progression and immune responses. Targeting ATP-mediated purinergic signaling offers a promising therapeutic strategy for cancer treatment.
Area of Science:
- Oncology
- Immunology
- Cell Biology
Background:
- High concentrations of extracellular ATP (eATP) are prevalent in the tumor microenvironment (TME).
- ATP-mediated purinergic signaling impacts cancer cell migration, therapy resistance, and immune regulation.
- Purinergic receptors are widely expressed on various cell types within the TME.
Purpose of the Study:
- To summarize the roles of purinergic signaling in the TME.
- To highlight the impact of eATP on cancer progression and immune modulation.
- To emphasize ATP signaling as a therapeutic target.
Main Methods:
- Literature review of studies on extracellular ATP and purinergic signaling in cancer.
- Analysis of the roles of ATP in cancer-related processes.
- Focus on immunogenic cell death and immune modulation.
Main Results:
- Extracellular ATP (eATP) plays multifaceted roles in the TME.
- Purinergic signaling regulates cancer cell migration, therapy resistance, and immune responses.
- ATP release and signaling are critical for tumor growth.
Conclusions:
- Purinergic signaling is a central regulator of tumor growth.
- Targeting ATP-mediated signaling is a promising therapeutic avenue.
- Understanding eATP's role in immunogenic cell death and immune modulation is crucial.
Keywords:
AutophagyCancer immunotherapyExtracellular ATP (eATP)Immunogenic cell death (ICD)P2X/P2Y receptorsPurinergic signalingTumor microenvironment (TME)More Related Videos
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