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Rh-Catalyzed Base-Free Decarbonylative Borylation of Twisted Amides
Fusheng Bie1,2, Xuejing Liu1,2, Yijun Shi1,2
1Zaozhuang University, 1 Bei'an Road, Zaozhuang, Shandong 277160, China.
Abstract:
We report the rhodium-catalyzed base-free decarbonylative borylation of twisted amides. The synthesis of versatile arylboronate esters from aryl twisted amides is achieved via decarbonylative rhodium(I) catalysis and highly selective N-C(O) insertion. The method is notable for a very practical, additive-free Rh(I) catalyst system. The method shows broad functional group tolerance and excellent substrate scope, including site-selective decarbonylative borylation/Heck cross-coupling via divergent N-C/C-Br cleavage and late-stage pharmaceutical borylation.
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