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Updated: Dec 3, 2025

Oxygen-Glucose Deprivation and Reoxygenation as an In Vitro Ischemia-Reperfusion Injury Model for Studying Blood-Brain Barrier Dysfunction
Published on: May 7, 2015
Failures of the Oxygen Supply
Richard Botney1, Joseph F Answine2, Charles E Cowles3
1Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, M/C SJH-2, Portland, OR 97239, USA.
Abstract:
Oxygen supply failures are potentially life-threatening and are often associated with death or brain damage. Knowledge of how oxygen is supplied is essential for understanding how failures are caused and their management. Even though safety mechanisms exist to reduce the likelihood of a supply failure, events still occur. Simulation studies have identified knowledge and performance gaps in management of supply failures. A straightforward approach to immediate management of these critical events is provided.
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