Related Experiment Video
Updated: Dec 3, 2025

Oxygen-Glucose Deprivation and Reoxygenation as an In Vitro Ischemia-Reperfusion Injury Model for Studying Blood-Brain Barrier Dysfunction
Published on: May 7, 2015
Failures of the Oxygen Supply
Richard Botney1, Joseph F Answine2, Charles E Cowles3
1Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, M/C SJH-2, Portland, OR 97239, USA.
Oxygen supply failures can cause death or brain damage. This study provides a straightforward approach to managing these critical events, addressing knowledge gaps in patient care.
Area of Science:
- Anesthesiology
- Patient Safety
- Medical Device Technology
Background:
- Oxygen supply systems are critical for patient safety during medical procedures.
- Failures in oxygen supply can lead to severe patient harm, including brain damage or death.
- Existing safety mechanisms do not entirely prevent oxygen supply failures.
Purpose of the Study:
- To highlight the critical nature of oxygen supply failures.
- To identify knowledge and performance gaps in managing these events.
- To provide a clear, immediate management strategy for oxygen supply failures.
Main Methods:
- Review of existing literature and safety data on oxygen supply systems.
- Analysis of simulation studies identifying management challenges.
- Development of a simplified, actionable protocol for immediate response.
Main Results:
- Oxygen supply failures remain a significant risk despite safety measures.
- Simulation studies reveal critical deficiencies in healthcare providers' responses.
- The proposed approach aims to bridge identified knowledge and performance gaps.
Conclusions:
- Effective management of oxygen supply failures requires clear protocols.
- Addressing identified gaps can improve patient outcomes during critical events.
- A straightforward approach is essential for immediate and effective intervention.
Related Concept Videos
Acute Respiratory Failure-II
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Acute Respiratory Failure-I
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
Hypoxia
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Oxygen Transport in the Blood
Respiration and Gaseous Exchange
Respiration involves the exchange of gases, especially oxygen (O2) and carbon dioxide (CO2), between the alveoli and body cells, a process facilitated by blood circulation. As a result, the cardiovascular system, which involves...
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...

