Evaluation of inflammatory parameters in lipoid proteinosis patients

Lipoid proteinosis (LP) is a rare metabolic storage disease characterized by the storage of hyaline-like substances in the skin, mucosa, and many other organs. The aim of this study was to compare the neutrophil/lymphocyte ratio (NLR), platelets/lymphocyte ratio (PLR), and mean platelet volume (MPV) values of LP patients with healthy control group and to determine the usefulness of these parameters in determining the inflammatory status in LP patients. This study included 14 patients who were admitted to our clinic between March 2013 and January 2017 and diagnosed as LP with clinical, radiological, and histopathological examinations with 14 individuals who had no systemic inflammatory disease or malignancy and has a hemogram result. There was no statistically significant difference between the two groups in comparison to the MPV and PLR values of the patients with LP and healthy controls (P values 0.666 and 0.654, respectively). When the NLR values of the patients with LP and healthy controls were compared, it was found that the LP-diagnosed NLR values were statistically higher. (P: 0.019). In conclusion, it can be said that NLR is an appropriate parameter in demonstrating inflammation in LP patients, but PLR and MPV are not a suitable parameter in demonstrating inflammation in LP patients. Prospective studies with more patients are needed.