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Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair

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In vivo tissue regeneration with robotic implants.

Dana D Damian^1,2, Karl Price¹, Slava Arabagi³

¹Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Science Robotics

|November 3, 2020

Summary

Researchers developed an ingestible robotic implant that uses mechanical stimulation to promote tissue growth in organs like the esophagus. This innovation shows promise for treating conditions such as long-gap esophageal atresia and short bowel syndrome.

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Area of Science:

Biomedical Engineering
Regenerative Medicine
Robotics

Background:

Internal robotic implants offer potential for restoring biological function.
Designing functional internal robots faces challenges in host-implant signaling and device engineering.

Purpose of the Study:

To investigate in vivo tissue regeneration using robotic implants.
To develop a robotic system for inducing tubular organ lengthening via mechanostimulation.

Main Methods:

A robotic implant was designed to apply computer-controlled traction forces to tubular organs.
In vivo esophageal testing was conducted in swine models.

Main Results:

The robotic implant successfully induced cell proliferation and organ lengthening in the esophagus.
Tissue lengthening occurred without a reduction in organ diameter.
Testing was performed on awake, mobile animals capable of normal feeding.

Conclusions:

Robotic implants can effectively promote tissue regeneration through mechanostimulation.
This technology can serve as a research tool for mechanotransduction signaling.
Clinical applications include treating long-gap esophageal atresia and short bowel syndrome.