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NeuroDAC: an open-source arbitrary biosignal waveform generator.

M P Powell^1,2, J Anso³, R Gilron³

¹School of Engineering, Brown University, Providence, RI, United States of America.

Journal of Neural Engineering

|November 5, 2020

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This summary is machine-generated.

Researchers developed NeuroDAC, an open-source biosignal generator using audio equipment for testing adaptive therapy devices. This flexible tool enables accurate evaluation of complex algorithms with pre-recorded signals, reducing the need for costly in vivo experiments.

Area of Science:

Biomedical Engineering
Neuroscience
Signal Processing

Background:

Advanced adaptive therapies require sophisticated biomedical devices with closed-loop algorithms.
Increasing complexity of multi-channel, multi-modal electrophysiological signal processing necessitates flexible testing solutions.
Existing testing methods for these devices can be expensive and limited, often requiring in vivo experiments.

Purpose of the Study:

To present a methodology for constructing a biosignal waveform generator using off-the-shelf audio equipment.
To introduce and validate the open-source NeuroDAC device for bench-top testing of biomedical devices and algorithms.
To provide an accessible tool for researchers to prototype and evaluate adaptive therapy systems.

Main Methods:

Keywords:

biomedical devices biosignal playback closed-loop neuromodulation neural interface waveform generator

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Developed the NeuroDAC, an 8-channel biosignal playback device utilizing a custom attenuation and buffering circuit.

Implemented a USB interface with standard audio drivers for host computer communication.

Incorporated on-board analog amplitude adjustment for optimizing dynamic range on a per-channel basis.

Main Results:

Achieved a low no-signal noise floor of 5.35 ± 0.063.
Characterized a high-pass -3 dB rolloff at 0.57 Hz, ensuring accurate reproduction of various biosignals (EMG, EEG, ECG, neural activity).
Demonstrated application by testing embedded algorithms on a closed-loop neural modulation device (Medtronic RC+S).

Conclusions:

The open-source NeuroDAC offers an accessible and flexible solution for prototyping and testing advanced biomedical devices and algorithms.
This approach reduces reliance on expensive in vivo testing by enabling evaluation with well-characterized biosignals.
NeuroDAC can be easily modified to meet diverse individual testing requirements, accelerating innovation in adaptive therapies.