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A Protocol for the Production of Gliadin-cyanoacrylate Nanoparticles for Hydrophilic Coating

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Published on: July 8, 2016

Pharmaceutical nanoparticle isolation using CO₂-assisted dynamic bed coating.

Vivek Verma¹, Kevin M Ryan¹, Luis Padrela¹

¹SSPC Research Centre, Department of Chemical Sciences, Bernal Institute, University of Limerick, Limerick, Ireland.

International Journal of Pharmaceutics

|November 10, 2020

Summary

This summary is machine-generated.

A new

Keywords:

Active pharmaceutical Ingredients Bioavailability Flowability Nanoparticles Supercritical CO(2) process Tabletability

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Area of Science:

Pharmaceutical Science
Materials Science
Chemical Engineering

Background:

Poor solubility of new chemical entities (NCEs) hinders drug bioavailability and efficacy.
Existing methods like nano-spray drying have limitations in nanoparticle properties and yield.
Nanotechnology offers a promising approach to enhance drug solubility and dissolution.

Purpose of the Study:

To develop and evaluate a novel method for producing and isolating drug nanoparticles.
To improve the rheological properties and dissolution rates of poorly soluble Active Pharmaceutical Ingredients (APIs).
To engineer drug nanoparticles with enhanced characteristics for pharmaceutical applications.

Main Methods:

Utilized a 'top spray dynamic bed coating' process with CO2 spray as the fluidizing gas.
Produced nanoparticles of carbamazepine (CBZ), ketoprofen (KET), and risperidone (RIS) with sizes ranging from 90-490 nm.
Coated API nanoparticles onto micron-sized microcrystalline cellulose (MCC) carrier particles.

Main Results:

Successfully produced and coated stable crystalline forms of CBZ, KET, and RIS onto MCC.
Achieved optimal rheological properties for the isolated solid drug nanoparticles.
Demonstrated a 2-6 fold improvement in the dissolution rate of the APIs.

Conclusions:

The 'top spray dynamic bed coater' is an efficient method for producing and coating API nanoparticles.
This novel approach overcomes limitations of existing methods, yielding particles with improved properties.
The process enhances drug dissolution and bioavailability, addressing a key challenge in pharmaceutical development.