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Confluence of obesity and MAFLD during Covid-19 pandemic in a developing country

Jhean Gabriel Gonzáles Yovera1, Marcio Jose Concepción-Zavaleta2, Julia Coronado Arroyo3

  • 1Division of Gastroenterology, Hospital Livel IV Guillermo Almenara Irigoyen, Lima, Perú.

Endocrinology, Diabetes & Metabolism
|November 11, 2020
PubMed

Insights

Overweight/obesity and metabolic-associated fatty liver disease (MAFLD) are linked to severe COVID-19 outcomes. These conditions increase the risk of mortality in patients with SARS-CoV-2 infection.

Area of Science:

  • Metabolic disorders
  • Infectious diseases
  • Hepatology

Background:

  • Growing prevalence of overweight/obesity and metabolic-associated fatty liver disease (MAFLD).
  • Emergence of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) and its significant global health impact.
  • Limited understanding of the interplay between metabolic health and viral infection severity.

Discussion:

  • Investigating the direct correlation between overweight/obesity, MAFLD, and the severity of SARS-CoV-2 infections.
  • Analyzing how these metabolic conditions may exacerbate COVID-19 progression and patient outcomes.
  • Assessing the role of metabolic dysfunction in heightened mortality rates among COVID-19 patients.

Key Insights:

  • Obesity and MAFLD are identified as significant risk factors for increased mortality in COVID-19 patients.
  • A direct relationship exists between the prevalence of overweight/obesity, MAFLD, and the severity of SARS-CoV-2 infection.
  • Metabolic derangements associated with obesity and MAFLD may compromise immune responses to SARS-CoV-2.

Outlook:

  • Further research into the pathophysiological mechanisms linking metabolic syndrome, MAFLD, and COVID-19 severity.
  • Development of targeted therapeutic strategies for high-risk individuals with obesity and MAFLD.
  • Public health initiatives to address the dual burden of metabolic diseases and infectious respiratory illnesses.

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