Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acromegaly.

G Baumann1

  • 1Center for Endocrinology, Metabolism, and Nutrition, Northwestern University Medical School, Chicago, Illinois.

Endocrinology and Metabolism Clinics of North America
|September 1, 1987
PubMed
Summary
This summary is machine-generated.

Acromegaly, caused by excess growth hormone (GH), leads to significant systemic issues and increased mortality. Early diagnosis through GH and somatomedin C testing, followed by surgical or medical treatment, is crucial for managing this pituitary disorder.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing cardiac autonomic function via heart rate variability analysis requires monitoring respiration.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2016
Same author

A primary intravascular synovial sarcoma causing deep-vein thrombosis and pulmonary embolism in a 20-year-old woman.

Current oncology (Toronto, Ont.)·2015
Same author

[Will telemonitoring be adopted by patients with chronic heart failure?].

Deutsche medizinische Wochenschrift (1946)·2014
Same author

[Diagnosis of sleep disordered breathing using portable methods].

Pneumologie (Stuttgart, Germany)·2012
Same author

[Sleep-disordered breathing and atrial fibrillation].

Herzschrittmachertherapie & Elektrophysiologie·2012
Same author

[Sleep apnoea syndrome in the rehabilitation setting].

Herz·2011
Same journal

Navigating Adrenal Disease: A Comprehensive, Practical Guide for the Clinician.

Endocrinology and metabolism clinics of North America·2026
Same journal

Adrenal Disorders in Pregnancy.

Endocrinology and metabolism clinics of North America·2026
Same journal

Diagnosis and Management of Adrenocortical Carcinoma.

Endocrinology and metabolism clinics of North America·2026
Same journal

Pheochromocytomas and Paragangliomas.

Endocrinology and metabolism clinics of North America·2026
Same journal

Hereditary Conditions Associated with Adrenocortical Carcinoma, Pheochromocytoma, and Other Adrenal Tumors: Genetic Testing and Management Recommendations.

Endocrinology and metabolism clinics of North America·2026
Same journal

Primary Bilateral Macronodular Adrenal Hyperplasia.

Endocrinology and metabolism clinics of North America·2026
See all related articles

Area of Science:

  • Endocrinology
  • Oncology
  • Neurosurgery

Background:

  • Acromegaly results from growth hormone (GH)-secreting pituitary adenomas or ectopic growth hormone-releasing hormone (GRH) production.
  • Systemic manifestations include acral enlargement, diabetes, hypertension, and cardiac disease.
  • Tumor-related issues encompass visual impairment and hypopituitarism, leading to substantial morbidity and mortality.

Purpose of the Study:

  • To outline the causes, manifestations, diagnostic approaches, and therapeutic strategies for acromegaly.
  • To emphasize the importance of early diagnosis and comprehensive management.

Main Methods:

  • Diagnosis involves measuring plasma GH after an oral glucose load and plasma somatomedin C levels.
  • Pituitary lesions are assessed using CT scanning in the coronal plane.

Related Experiment Videos

  • Therapy includes surgical removal of the adenoma or ectopic source, with adjunctive radiation or drug therapy.

    • Main Results:

    • Surgical transsphenoidal removal is the primary treatment for pituitary adenomas.
    • Radiation therapy (conventional or heavy particle beams) and medications like bromocriptine and somatostatin analogues can be used adjunctively.
    • Effective management requires long-term follow-up to monitor for recurrence or complications.

    Conclusions:

    • Acromegaly necessitates prompt diagnosis and mandatory treatment to mitigate severe health consequences.
    • A multidisciplinary approach involving surgery, radiation, and medication is often required for optimal outcomes.
    • Long-term surveillance is essential for managing acromegaly patients effectively.