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Colorimetric Sensor for Online Accurate Detection of Breath Acetone
Di Wang1,2, Fenni Zhang2, Amlendu Prabhakar2
1Research Center for Intelligent Sensing, Zhejiang Lab, Hangzhou 310000, China.
ACS Sensors
|November 19, 2020
Summary
A new colorimetric sensor accurately detects breath acetone (BrAce), a key biomarker for fat burning and diabetes management. This innovation offers a reliable method for real-time health monitoring using breath analysis.
Area of Science:
- Biomedical Engineering
- Analytical Chemistry
- Respiratory Medicine
Background:
- Breath acetone (BrAce) is a validated biomarker for lipid oxidation.
- Applications include monitoring diabetic ketoacidosis, ketogenic diets, and exercise-induced fat burning.
- Previous BrAce sensors often lacked validation with real human breath samples due to complexity.
Purpose of the Study:
- To develop and validate a colorimetric sensor for accurate online detection of breath acetone.
- To assess the sensor's selectivity and performance against a reference instrument.
Main Methods:
- Utilized a colorimetric sensor based on the specific reaction of acetone with hydroxylamine sulfate.
- Validated the sensor's performance using real human breath samples.
- Compared sensor readings with a reference instrument for ketosis monitoring.
Main Results:
- Achieved online, accurate detection of breath acetone.
- Demonstrated high selectivity for acetone.
- Showed high agreement with a reference instrument in ketosis monitoring.
Conclusions:
- The developed colorimetric sensor provides a reliable method for breath acetone measurement.
- This sensor technology shows promise for various health-related applications, including diabetes management and metabolic monitoring.
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