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Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
Published on: February 18, 2022
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Approaches to quantify optical coherence tomography angiography metrics.
Bingyao Tan1,2,3, Ralene Sim2, Jacqueline Chua2,4
1Institute for Health Technologies, Nanyang Technological University, Singapore, Singapore.
Annals of Translational Medicine
|November 26, 2020
Summary
Optical coherence tomography angiography (OCTA) offers non-invasive, 3D imaging of ocular vasculature. This review details OCTA interpretation methods, from image generation to artifact correction and quantification, aiding disease diagnosis.
Area of Science:
- Ophthalmology
- Medical Imaging
- Biomedical Engineering
Background:
- Optical coherence tomography angiography (OCTA) is a revolutionary, non-invasive imaging technique for ocular vasculature.
- It provides 3D, dye-free visualization of blood flow using motion contrast from OCT systems.
- OCTA technology has seen widespread clinical adoption since its FDA approval in 2016.
Purpose of the Study:
- To review the technical workflow of OCTA image interpretation and quantification.
- To discuss various methods for OCTA image generation, artifact reduction, and enhancement.
- To highlight the potential of OCTA in diagnosing and managing ocular diseases and its systemic implications.
Main Methods:
- Signal decorrelation techniques (intensity-based, phase-based, phasor-based) for OCTA image generation.
- Methods for addressing common clinical artifacts in OCTA imaging.
- Algorithms for image enhancement, binarization, and extraction of quantitative OCTA metrics.
Main Results:
- Detailed overview of OCTA image generation methodologies.
- Discussion of strategies for artifact mitigation and image quality improvement.
- Exploration of quantitative metrics derived from OCTA for clinical use.
Conclusions:
- A comprehensive understanding of OCTA's technical aspects is crucial for its effective clinical application.
- OCTA facilitates improved diagnosis and management of ocular diseases.
- Future research may link ocular OCTA findings to systemic health conditions in organs like the kidney and brain.
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