STRUCTURAL CHANGES AND MORPHOMETRIC ANALYSIS OF CARDIOMYOCYTES IN RATS WITH ALLOXAN DIABETES

Area of Science:

• Cardiovascular Research
• Endocrinology
• Pathology

Background:

• Diabetes mellitus is associated with cardiovascular complications.
• Alloxan-induced diabetes in rats serves as a model for studying diabetes-related cardiac pathology.

Purpose of the Study:

• To investigate the dynamic structural alterations in rat cardiomyocytes during alloxan-induced diabetes.
• To perform a morphometric analysis of these changes at 1 and 3 months post-induction.

Main Methods:

• Experimental diabetes induced via intravenous alloxan administration in Wistar rats.
• Histological, biochemical, and morphometric analyses employed.
• Statistical methods used for data interpretation.

Main Results:

• Alloxan diabetes induced cardiomyocyte dystrophy, necrosis, and apoptosis.
• Myocardial microcirculation was impaired, with endothelial damage and red blood cell aggregation.
• Changes were more severe in the right heart chambers, with significant cardiomyocyte hypertrophy observed at 3 months.

Conclusions:

• Alloxan diabetes leads to progressive structural damage and hypertrophy of cardiomyocytes.
• The right heart chambers exhibit a pronounced response to diabetic metabolic changes.
• These findings underscore the significant impact of diabetes mellitus on cardiac structure, particularly in the right ventricle.