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COVID-19 Pneumonia during Hydroxychloroquine Treatment of Rheumatoid Arthritis

Canan Gürsoy1, Özge Oral Tapan2, Emrah Dogan3

  • 1Department of Anesthesiology and Reanimation, Division of Intensive Care Unit, Muğla Sıtkı Koçman University Training and Research Hospital, Muğla, Turkey.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|December 9, 2020
PubMed

Insights

Hydroxychloroquine (HCQ) did not prevent severe COVID-19 pneumonia in a rheumatoid arthritis patient. This case highlights uncertainties in HCQ prophylaxis for coronavirus disease 2019 (COVID-19).

Area of Science:

  • Infectious Diseases
  • Rheumatology
  • Pharmacology

Background:

  • Severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) emerged in Turkey in March 2020, causing a global pandemic.
  • Uncertainties remain regarding the prevention and treatment of coronavirus disease 2019 (COVID-19).
  • Hydroxychloroquine (HCQ) is used to treat rheumatoid arthritis.

Observation:

  • A 38-year-old female patient with rheumatoid arthritis was undergoing HCQ treatment.
  • The patient developed severe respiratory distress due to SARS-CoV-2 infection.
  • She required Intensive Care Unit (ICU) admission for COVID-19 pneumonia.

Findings:

  • This case presents COVID-19 pneumonia in a patient on HCQ treatment.
  • The patient experienced severe respiratory distress despite HCQ therapy.
  • HCQ did not appear to confer protection against severe SARS-CoV-2 infection in this instance.

Implications:

  • Discusses the role of HCQ in COVID-19 prophylaxis.
  • Highlights the need for further research into HCQ's efficacy and safety for COVID-19.
  • Emphasizes the importance of considering patient comorbidities and treatments in managing infectious diseases.

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