Prognostic Value of Long Noncoding RNA SNHG12 in Various Carcinomas: A Meta-Analysis

Area of Science:

• Oncology
• Molecular Biology
• Biomarker Research

Background:

• Long noncoding RNA small nucleolar RNA host gene 12 (SNHG12) overexpression suggests prooncogenic roles in various cancers.
• The prognostic significance of SNHG12 in cancer remains controversial.
• This study aims to clarify the clinical significance of SNHG12 in cancer patients.

Purpose of the Study:

• To conduct a meta-analysis and bioinformatics analysis to evaluate the prognostic value of SNHG12 in human cancers.
• To determine the association between SNHG12 expression and overall survival (OS) and disease-free survival (DFS).
• To investigate the relationship between SNHG12 and clinicopathological characteristics.

Main Methods:

• Comprehensive literature search of PubMed, Embase, Cochrane Library, CNKI, Wanfang, and Weipu databases up to July 2020.
• Meta-analysis of 23 studies involving 1389 cancer patients.
• Bioinformatics analysis to validate meta-analysis findings.

Main Results:

• Elevated SNHG12 expression significantly correlates with poorer OS (HR=1.81) and DFS (HR=1.40) across multiple cancer types.
• Bioinformatics analysis confirmed the association between high SNHG12 expression and adverse survival outcomes.
• SNHG12 overexpression is linked to lymph node metastasis (LNM), distant metastasis, advanced clinical stage, larger tumor size, and poor differentiation.

Conclusions:

• SNHG12 overexpression serves as a significant indicator of poor prognosis in human cancers.
• SNHG12 may function as a novel diagnostic or prognostic biomarker for various cancers.
• Further research is warranted to explore SNHG12's therapeutic potential.