Related Experiment Video

Updated: Nov 25, 2025

A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria
03:55

A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria

Published on: June 27, 2022

3.9K

Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential

Hai-Jian Sun1, Zhi-Yuan Wu1, Xiao-Wei Nie1

  • 1Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore.

Journal of Advanced Research
|December 15, 2020
PubMed
Abstract

Keywords:
3-MP, 3-mercaptopyruvate3-MST, 3-mercaptopyruvate sulfurtransferaseAGTR1, angiotensin II type 1 receptorAMPK, AMP-activated protein kinaseAkt, protein kinase BCAT, cysteine aminotransferaseCBS, cystathione β-synthaseCO, carbon monoxideCOX-2, cyclooxygenase-2CSE, cystathione γ-lyaseCX3CR1, chemokine CX3C motif receptor 1CancerDAO, D-amino acid oxidaseDATS, Diallyl trisulfideEGFR, epidermal growth factor receptorERK, extracellular regulated protein kinasesFAS, fatty acid synthaseFibrosisH2S, hydrogen sulfideHFD, high fat dietHO-1, heme oxygenase 1Hydrogen sulfideIR, ischemia/reperfusionLiver diseaseMMP-2, matrix metalloproteinase 2NADH, nicotinamide adenine dinucleotideNADPH, nicotinamide adenine dinucleotide phosphateNAFLD, non-alcoholic fatty liver diseasesNASH, nonalcoholic steatohepatitisNF-κB, nuclear factor-kappa BNaHS, sodium hydrosulfideNrf2, nuclear factor erythroid2-related factor 2PI3K, phosphatidylinositol 3-kinasePLP, pyridoxal 5′-phosphatePPG, propargylglycinePTEN, phosphatase and tensin homolog deleted on chromosome tenSAC, S-allyl-cysteineSPRC, S-propargyl-cysteineSTAT3, signal transducer and activator of transcription 3SteatosisVLDL, very low density lipoproteinmTOR, mammalian target of rapamycin

More Related Videos

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro11:06

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

5.0K
Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis08:58

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis

Published on: March 11, 2017

16.5K

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
84
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
106
Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug01:14

Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug

In pharmacotherapy, monitoring drug concentrations is paramount, especially for drugs whose therapeutic effects hinge on both the active compound and its metabolite. Hepatic impairment profoundly influences drug potency by altering liver function. If the drug is more potent than its metabolite, impaired liver function amplifies drug activity due to elevated drug concentration levels. Conversely, if the metabolite holds greater potency, diminished liver function diminishes drug activity by...
98
Sulfur Assimilation01:20

Sulfur Assimilation

Sulfur is an essential element in biological systems, contributing to synthesizing key biomolecules, including amino acids such as cysteine and methionine, and cofactors such as coenzyme A and biotin. Microorganisms primarily assimilate sulfur as sulfate (SO₄²⁻) from the environment, which must undergo a series of biochemical transformations before it can be incorporated into cellular components. As sulfate is highly oxidized, it must undergo assimilatory sulfate reduction to...
186
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
83
Peroxisomes01:24

Peroxisomes

Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
18.7K