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Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

464
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
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[COVID-19 and kidney involvement].

K Amann1, P Boor2, T Wiech3

  • 1Abt. Nephropathologie, Patholog. Institut, Universitätsklinikum Erlangen, Krankenhausstr. 8-10, 91054 Erlangen, Deutschland.

Der Nephrologe
|December 21, 2020
PubMed
Summary
This summary is machine-generated.

Acute kidney injury is a severe complication of coronavirus disease 2019 (COVID-19). Research is ongoing to understand the direct effects of SARS-CoV-2 on kidney tissue and vulnerable patient populations.

Keywords:
Acute renal insufficiencyAcute tubular injuryChronic kidney diseaseCoronavirusVirus detection

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Area of Science:

  • Nephrology
  • Virology
  • Pathology

Context:

  • Severe coronavirus disease 2019 (COVID-19) frequently causes acute kidney injury, a serious complication.
  • The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been detected in renal tissue.
  • Patients with chronic kidney disease, on dialysis, or kidney transplant recipients are particularly vulnerable to SARS-CoV-2 infection.

Purpose:

  • To investigate the pathophysiology and morphology of kidney damage caused by SARS-CoV-2.
  • To explore methods for direct virus detection in renal tissue.
  • To clarify the direct effects of SARS-CoV-2 on kidney function.

Summary:

  • Autopsy and kidney biopsy studies provide insights into SARS-CoV-2-related kidney damage.
  • Detection of SARS-CoV-2 RNA in tissue yields reproducible results.
  • Electron microscopy for virus visualization in kidneys is debated due to potential artifacts.

Impact:

  • Understanding SARS-CoV-2's impact on the kidneys is crucial for managing vulnerable patient groups.
  • Further research is needed to elucidate the precise mechanisms of kidney injury.
  • This knowledge will inform clinical management and treatment strategies for COVID-19 patients with kidney complications.