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A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies
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EFFICIENCY OF BONE MARROW PRECURSOR CELL COLONY-FORMING AS A PREDICTOR OF DISEASE COURSE IN PLASMA CELL MYELOMA
Zh M Minchenko1, T F Liubarets1, V V Balan1
1State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka St., Kyiv, 04050, Ukraine.
Problemy Radiatsiinoi Medytsyny Ta Radiobiolohii
|December 28, 2020
Summary
Bone marrow colony-forming efficiency (CFE) in plasma cell myeloma (PCM) patients correlates with disease stage and remission status. Higher CFE before treatment predicts a significantly longer lifespan for PCM patients.
Area of Science:
- Hematology
- Oncology
- Stem Cell Biology
Background:
- Plasma cell myeloma (PCM) is a cancer of plasma cells.
- Bone marrow (BM) microenvironment plays a crucial role in cancer progression.
- Assessing the functional capacity of BM stem cells can offer prognostic insights.
Purpose of the Study:
- To evaluate the role of bone marrow colony-forming efficiency (CFE) as a prognostic criterion in plasma cell myeloma (PCM) patients.
- To assess CFE at different stages of PCM treatment.
- To investigate the impact of ionizing radiation exposure on CFE in PCM patients.
Main Methods:
- Colony-forming efficiency (CFE) was assayed in 37 patients with stage I-II PCM (21 exposed to radiation, 16 not exposed) and 20 healthy controls.
- CFE of granulocyte-macrophage colony-forming units (CFU-GM) and fibroblast colony-forming units (CFU-F) were measured at diagnosis and during remission.
- Statistical analysis was performed to correlate CFE with disease stage, remission status, and patient lifespan.
Main Results:
- BM CFU-GM and CFU-F levels were significantly lower in PCM patients compared to controls, and decreased with advancing disease stage.
- CFE increased significantly in patients who achieved remission, approaching control levels.
- No significant difference in CFE was observed between irradiated and non-irradiated PCM patients.
- CFE of BM CFU-GM before polychemotherapy was a significant predictor of patient lifespan (Ro = 0.39, p < 0.02).
Conclusions:
- Bone marrow cell CFE is dependent on the stage of PCM and the presence or absence of remission.
- CFE, particularly of BM CFU-GM, demonstrates prognostic value for PCM patient survival.
- Patients with a CFE > 20 before chemotherapy have a significantly longer lifespan compared to those with CFE < 20.
Keywords:
bone marrowclusterfibroblast colony-forming unitgranulocyte-macrophage colony-forming unitplasma cell myelomaMore Related Videos
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