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TNF-α AND IONIZING RADIATION: THE ROLE IN THE PATHOGENESIS AND TREATMENT OF PLASMA CELL MYELOMA (review)
1Bogomolets National Medical University, 13 Tarasa Shevchenko Blvd, Kyiv, 01601, Ukraine.
This review examines Tumor Necrosis Factor-alpha (TNF-α) and ionizing radiation in plasma cell myeloma (PCM). It highlights how these factors impact immune interactions and explores advanced therapies like CAR T-cell therapy for improved patient outcomes.
Area of Science:
- Oncology
- Immunology
- Radiation Biology
Background:
- Plasma cell myeloma (PCM) pathogenesis involves complex interactions.
- Tumor Necrosis Factor-alpha (TNF-α) and ionizing radiation (IR) play significant roles in PCM.
- Dysregulation of TNF-α impacts immune system interaction with plasma cells.
Purpose of the Study:
- To review the literature on TNF-α and IR in PCM.
- To analyze the disturbance of TNF-α regulation under IR.
- To present modern therapeutic strategies for PCM.
Main Methods:
- Literature review of scientific data.
- Analysis of cytokine regulation in PCM.
- Overview of emerging therapies.
Main Results:
- TNF-α and IR influence PCM pathogenesis and treatment.
- Ionizing radiation disrupts TNF-α regulation and immune cell interactions.
- CAR T-cell therapy shows promise for PCM treatment optimization.
Conclusions:
- Understanding TNF-α and IR roles is crucial for PCM management.
- Advanced therapies like CAR T-cell therapy offer potential for improved patient prognosis.
- Further research can optimize PCM treatment strategies and enhance patient survival.
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