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IONIZING RADIATION AND CYTOKINES: THE ROLE IN THE PATHOGENESIS OF PLASMA CELL MYELOMA (LITERATURE REVIEW)
1O. O. Bogomolets National Medical University, 13 T. Shevchenko Boulevard, Kyiv, 01601, Ukraine.
Problemy Radiatsiinoi Medytsyny Ta Radiobiolohii
|December 30, 2022
Summary
Ionizing radiation exposure is linked to plasma cell myeloma (PCM) development. Studies on nuclear workers and Chornobyl victims show increased PCM incidence, with cytokine roles investigated.
Area of Science:
- Environmental Health
- Oncology
- Radiation Biology
Background:
- Ionizing radiation (IR) is a known environmental hazard.
- Plasma cell myeloma (PCM) is a cancer of plasma cells.
- The link between IR exposure and PCM incidence requires further elucidation.
Purpose of the Study:
- To review existing literature on the role of IR in PCM occurrence.
- To analyze PCM incidence in irradiated populations.
- To investigate the impact of cytokines on PCM cells under IR exposure.
Main Methods:
- Literature review of studies on irradiated populations.
- Analysis of PCM incidence data.
- In vitro studies on cytokine effects on PCM cells with IR and cytostatic agents.
Main Results:
- Literature data indicate IR as a negative environmental factor for PCM.
- Increased PCM incidence observed in specific irradiated groups, including nuclear industry employees and Chornobyl survivors.
- Cytokine (interleukin-6, interleukin-10) effects on PCM cells analyzed, including combined IR and cytostatic agent actions.
Conclusions:
- Ionizing radiation is implicated as a risk factor for plasma cell myeloma.
- Further research is warranted to understand the mechanisms of IR-induced PCM.
- Cytokine modulation may play a role in PCM development following radiation exposure.
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