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Updated: Nov 23, 2025
09:17
Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
Published on: February 28, 2025
628
Gene therapy in wound healing using nanotechnology.
Calver Pang1, Ka Siu Fan2, Lanxuan Wei3
1Department of Surgical Biotechnology, Division of Surgery & Interventional Science, Faculty of Medical Sciences, University College London, London, United Kingdom.
Summary
This study reviews wound healing physiology and explores gene therapy with nanotechnology for managing chronic wounds. These advanced regenerative medicine approaches aim to optimize wound microenvironments and reduce the global burden of difficult-to-treat wounds.
Area of Science:
- Regenerative Medicine
- Nanotechnology
- Gene Therapy
Background:
- Wound healing is a complex biological process prone to failures, resulting in chronic wounds and a significant global healthcare burden.
- Current treatments face challenges, driving innovation in regenerative medicine for tissue and organ replacement.
- Understanding wound pathophysiology is key to developing advanced therapeutic strategies.
Purpose of the Study:
- To provide an overview of wound healing physiology.
- To explore the application of gene therapy using nanotechnology in wound management.
- To highlight potential solutions for difficult-to-treat and chronic wounds.
Main Methods:
- Review of current literature on wound healing physiology.
- Analysis of gene therapy principles and their application in wound care.
- Examination of nanotechnology-based strategies for optimizing the wound microenvironment.
Main Results:
- Gene therapy and nanotechnology offer promising avenues for enhancing wound healing.
- Optimization of the wound microenvironment is crucial for successful treatment.
- These approaches have the potential to address challenges posed by chronic and complex wounds.
Conclusions:
- Regenerative medicine, particularly gene therapy combined with nanotechnology, represents a significant advancement in wound management.
- Further research and application of these technologies can help alleviate the global burden of chronic wounds.
- Optimizing the wound microenvironment is a key strategy for improving healing outcomes.
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