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Anatomical Reconstructions of the Human Cardiac Venous System using Contrast-computed Tomography of Perfusion-fixed Specimens
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Association between Cardio-ankle Vascular Index and Contrast-induced Nephropathy

Salih Sahinkus1, Ercan Aydin2, Muhammet Necati Murat Aksoy1

  • 1Department of Cardiology, Sakarya University Education and Research Hospital, Turkey.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|January 5, 2021
PubMed

Insights

Arterial stiffness, measured by cardio-ankle vascular index (CAVI), is more prevalent in acute coronary syndrome patients who develop contrast-induced nephropathy after coronary angiography. Close monitoring and hydration are recommended for high-risk patients.

Area of Science:

  • Cardiology
  • Nephrology
  • Vascular Medicine

Background:

  • Contrast-induced nephropathy (CIN) is a significant complication following coronary angiography (CAG).
  • Arterial stiffness (AS), assessed by cardio-ankle vascular index (CAVI), is a marker of arteriosclerosis.
  • The relationship between AS and CIN development in acute coronary syndrome (ACS) patients is not fully understood.

Purpose of the Study:

  • To investigate the association between CAVI, a marker of AS, and the incidence of CIN in patients undergoing CAG for ACS.
  • To identify clinical factors associated with CIN development in this patient cohort.

Main Methods:

  • A descriptive study was conducted involving 126 patients (66 with CIN, 60 without CIN) diagnosed with ACS between May and December 2019.
  • Demographic data, CAVI measurements, ejection fraction (EF), and glomerular filtration rate (GFR) were collected and compared between groups.
  • In-hospital clinical outcomes, including mortality, were also analyzed.

Main Results:

  • The overall incidence of CIN was 5.5%.
  • Patients who developed CIN had significantly lower EF (44.5% vs. 49.3%) and GFR (60.3 vs. 87.0 mL/min/1.73 m2) at admission compared to the non-CIN group.
  • Higher CAVI values, indicating increased arterial stiffness, were observed in the CIN group. Mortality rates did not differ significantly between groups.

Conclusions:

  • Arterial stiffness is more common in ACS patients who develop CIN post-CAG.
  • Older patients with reduced EF and GFR, and increased AS, are at higher risk for CIN.
  • Intravenous hydration and close monitoring are crucial for preventing CIN in these vulnerable patients.
Abstract

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