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Related Experiment Video

Updated: Nov 23, 2025

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Published on: September 1, 2022

CMOS-Based Neural Interface Device for Optogenetics.

Takashi Tokuda¹, Makito Haruta², Kiyotaka Sasagawa²

¹Institute of Innovative Research, Tokyo Institute of Technology, Tokyo, Japan. tokuda@ee.e.titech.ac.jp.

Advances in Experimental Medicine and Biology

|January 5, 2021

Summary

This summary is machine-generated.

Researchers developed novel CMOS-based optoelectronic neural interface devices for precise optical stimulation. These implantable sensors integrate blue light-emitting diodes, demonstrating effective in vitro and in vivo neural stimulation capabilities.

Keywords:

CMOS image sensor Implantable device Integrated optical stimulator On-chip imaging Optogenetics Wireless implant

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Last Updated: Nov 23, 2025

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Published on: September 1, 2022

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Area of Science:

Neuroscience
Biomedical Engineering
Materials Science

Background:

Neural interface devices are crucial for understanding and modulating neural activity.
Existing technologies face limitations in precision, biocompatibility, and integration.
Advancements in CMOS technology offer potential for miniaturized and high-performance neural interfaces.

Purpose of the Study:

To present the concept, design, and fabrication of novel CMOS-based optoelectronic neural interface devices.
To demonstrate the capability of addressable local optical stimulation for neural interfacing.
To explore future perspectives, including wireless device architectures.

Main Methods:

Utilized complementary metal-oxide-semiconductor (CMOS) technology for device fabrication.
Integrated an array of blue light-emitting diodes (LEDs) onto implantable CMOS image sensors.
Conducted functional demonstrations and optical stimulation experiments in both in vitro and in vivo settings.

Main Results:

Successfully designed and fabricated CMOS-based optoelectronic neural interface devices.
Demonstrated addressable local optical stimulation capabilities.
Validated the device's functionality through in vitro and in vivo experiments, confirming effective neural stimulation.

Conclusions:

The developed CMOS-based optoelectronic neural interface devices offer a promising platform for advanced neural interfacing.
The integration of optical stimulation with CMOS image sensors enables precise neural modulation.
Future work will focus on wireless architectures for enhanced clinical applicability.