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Updated: Nov 22, 2025

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices
Published on: November 5, 2016
Highly Protein Repellent and Antiadhesive Polysaccharide Biomaterial Coating for Urinary Catheter Applications
Tamilselvan Mohan1, Alja Čas1, Matej Bračič1
1Laboratory for Characterization and Processing of Polymers (LCPP), Faculty of Mechanical Engineering, University of Maribor, Smetanova ulica 17, Maribor 2000, Slovenia.
Abstract:
Engineering functional biomaterials surfaces that resist biofilm formation triggered by unspecific protein adsorption is a key challenge, and these biosurfaces hold a huge potential in implant-associated infection. Herein, we report a water-based facile approach to install carboxylated-hyaluronic acid and sulfated-fucoidan on cationically tethered polydimethylsiloxane (PDMS) implant. We showed that these hydrophilic, charged, polysaccharide-based biosurfaces/biocoatings provide long-term stability, no adsorption of proteins (albumin and fibrinogen), similar to zwitterionic polymers, and enhanced resistance to plasma deposition and growth of Staphylococcus aureus pathogen. These findings shall pave the way in developing novel biocoatings, thereby broadening the applicability of PDMS-based implants in complex biological applications.
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