A Multi-omics Data Resource for Frontotemporal Dementia Research.

Area of Science:

• Neurodegenerative diseases
• Genetics of neurological disorders
• Molecular biology of FTD

Background:

• Frontotemporal dementia (FTD) is a neurodegenerative disorder with significant genetic contributions.
• Mutations in MAPT, GRN, and C9orf72 genes account for nearly half of familial FTD cases.
• Understanding the molecular mechanisms linking these genetic mutations to FTD pathogenesis remains incomplete.

Purpose of the Study:

• To establish a comprehensive multi-omics data resource for Frontotemporal Dementia (FTD).
• To provide a detailed cellular and molecular profile of FTD caused by mutations in MAPT, GRN, and C9orf72.
• To facilitate deeper insights into the disease mechanisms of FTD.

Main Methods:

• Utilized multi-omics technologies (genomics, transcriptomics, proteomics, etc.) on post-mortem human brain tissue.
• Analyzed brain tissue from FTD patients with known gene mutations (MAPT, GRN, C9orf72) and healthy controls.
• Incorporated data from FTD mouse models and induced pluripotent stem cell (iPSC)-derived neuronal cultures for cross-validation and to overcome limitations of post-mortem tissue.

Main Results:

• Generated a rich, multi-omics dataset specific to FTD.
• Characterized the cellular and molecular landscape of FTD associated with key genetic mutations.
• Established a valuable resource integrating human, animal model, and cellular data.

Conclusions:

• The RiMod-FTD data resource offers a unique and comprehensive dataset for FTD research.
• This resource is publicly available, aiming to accelerate scientific understanding and progress in FTD.
• Further expansion and accessibility improvements are planned for the RiMod-FTD resource.