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HYPERREFLECTIVITY ON OPTICAL COHERENCE TOMOGRAPHY IN MACULAR TELANGIECTASIA TYPE 2
Simone Tzaridis1,2, Kristina Hess3, Tjebo F C Heeren4,5
1The Lowy Medical Research Institute, La Jolla, California.
Retina (Philadelphia, Pa.)
|January 13, 2021
Summary
Hyperreflectivity is common in Macular Telangiectasia Type 2, affecting 55% of eyes. A new grading scale may help predict disease progression and neovascularization risk.
Area of Science:
- Ophthalmology
- Medical Imaging
Background:
- Macular Telangiectasia Type 2 (MT2) is a degenerative retinal disease.
- Optical coherence tomography (OCT) is crucial for diagnosing and monitoring retinal conditions.
Purpose of the Study:
- To define, characterize, and classify hyperreflectivity on OCT in MT2.
- To determine the prevalence of hyperreflectivity in MT2.
- To establish a grading scale for hyperreflectivity to assess disease progression.
Main Methods:
- Retrospective analysis of multimodal imaging data from 161 patients (322 eyes).
- OCT and OCT angiography (OCTA) were used to define and grade hyperreflectivity and neovascularization.
- Longitudinal review of 103 patients (206 eyes) over a mean of 35.6 months.
Main Results:
- Hyperreflectivity was present in 55% of eyes and neovascular membranes in 15%.
- Hyperreflectivity correlated significantly with disease progression parameters.
- New hyperreflectivity developed in 20% of eyes, and outer retinal hyperreflectivity preceded neovascularization in 33% of cases.
Conclusions:
- Hyperreflectivity is a frequent finding in MT2, but lacks a standardized definition.
- A proposed hyperreflectivity grading scale can aid in estimating disease progression.
- The grading scale may identify eyes at higher risk for developing neovascular membranes.
