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Analysis Protocols for MRI Mapping of Renal T1
Philippe Garteiser1, Gwenaël Pagé1, Sabrina Doblas1
1Laboratory of Imaging Biomarkers, Centre de Recherche sur l'Inflammation, Inserm UMR 1149, Université de Paris, Paris, France.
Methods in Molecular Biology (Clifton, N.J.)
|January 21, 2021
Summary
This study presents strategies for analyzing renal T1 mapping datasets in small animals to characterize kidney disease. It offers guidance on software, data quality, fitting models, and result validation for improved MRI biomarker standardization.
Area of Science:
- Biomedical Imaging
- Magnetic Resonance Imaging
- Renal Physiology
Background:
- Accurate characterization of kidney disease models in small animals is crucial for research.
- T1 mapping from Magnetic Resonance (MR) datasets is an important tool for this characterization.
- Standardization of renal MRI biomarkers is needed for reproducibility.
Purpose of the Study:
- To present main strategies for analyzing renal T1 mapping datasets from small rodents.
- To provide guidance on software requirements and data quality evaluation.
- To discuss fitting models and propose validation methods for T1 mapping results.
Main Methods:
- Analysis of T1 mapping datasets derived from small rodent MR scans.
- Evaluation of dataset completeness and quality.
- Discussion of various applicable T1 mapping fitting models.
- Proposal of methods for validating obtained results.
Main Results:
- Strategies for analyzing renal T1 mapping data are presented.
- Guidance on software, data quality, fitting models, and validation is provided.
- The work aims to improve reproducibility and standardization of renal MRI biomarkers.
Conclusions:
- The presented strategies facilitate precise characterization of kidney disease models in small animals using T1 mapping.
- This work supports the COST Action PARENCHIMA's goal of standardizing renal MRI biomarkers.
- The chapter provides a comprehensive protocol for analyzing renal T1 mapping data.
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