Multimodal Imaging Features of Optic Disc Drusen.

Area of Science:

• Ophthalmology
• Medical Imaging

Background:

• Optic disc drusen (ODD) are calcified deposits within the optic nerve head.
• Accurate imaging is crucial for diagnosing ODD and differentiating it from other optic neuropathies.

Purpose of the Study:

• To identify key en face multimodal imaging features of optic disc drusen (ODD).

Main Methods:

• Retrospective cross-sectional study involving 786 patients with ODD.
• Utilized color fundus imaging, green-light and blue-light fundus autofluorescence (FAF), near-infrared reflectance (NIR), and enhanced-depth imaging optical coherence tomography (EDI-OCT).

Main Results:

• Green-light FAF showed the highest sensitivity (96.8%) for ODD detection.
• Blue-light FAF and NIR imaging revealed papillary and peripapillary features, including ODD size, depth, and associated structures.
• Color fundus imaging had the lowest sensitivity (82%).

Conclusions:

• En face imaging, particularly green-light FAF, is highly sensitive for ODD diagnosis.
• Blue-light FAF and NIR offer detailed ODD characteristics, complementing EDI-OCT for comprehensive assessment.