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Autonomic Dysfunction and Neurohormonal Disorders in Atrial Fibrillation
Anna Pfenniger1, Gail Elizabeth Geist1, Rishi Arora1
1Feinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, 251 East Huron, Feinberg 8-503, Chicago, IL 60611, USA.
Cardiac Electrophysiology Clinics
|January 31, 2021
Summary
Atrial fibrillation (AF) is a common heart rhythm disorder lacking a cure. This review explores how the autonomic nervous system influences AF and discusses new therapies.
Area of Science:
- Cardiology
- Neuroscience
- Physiology
Background:
- Atrial fibrillation (AF) is the most common cardiac arrhythmia, posing significant health risks.
- Despite its prevalence, an effective cure for AF remains elusive.
- AF's origins and progression are complex and multifactorial.
Purpose of the Study:
- To review the physiological role of the autonomic nervous system in AF.
- To summarize current research on autonomic and neurohormonal contributions to AF.
- To discuss emerging targeted therapies and future clinical strategies for AF.
Main Methods:
- Literature review of physiological mechanisms.
- Analysis of current research on autonomic and neurohormonal factors in AF.
- Evaluation of existing and novel therapeutic approaches.
Main Results:
- The autonomic nervous system plays a critical role in the initiation and perpetuation of AF.
- Neurohormonal imbalances are increasingly recognized as key contributors to AF.
- Several targeted therapies focusing on autonomic modulation show promise.
Conclusions:
- Understanding autonomic and neurohormonal influences is crucial for developing effective AF treatments.
- Future research should focus on refining targeted therapies for AF management.
- Clinical interventions targeting the autonomic nervous system may offer new hope for AF patients.
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