A New Potent Antimicrobial Metalloporphyrin
Lu Jiang1, Pei Lin Chee1, Jian Gao2
1Institute of Materials Research and Engineering, Agency for Science, Technology and Research, 2 Fusionopolis Way, #08-03, Innovis, Singapore, 138634, Singapore.
Chemistry, an Asian Journal
|February 22, 2021
Summary
New porphyrin compounds show strong antimicrobial activity. Manganese-based porphyrins are effective bactericides with low toxicity, even in the absence of light.
Area of Science:
- Medicinal Chemistry
- Materials Science
- Microbiology
Background:
- Porphyrins and metalloporphyrins are known for diverse biological activities.
- Developing novel antimicrobial agents is crucial due to rising resistance.
- Acryl functionalization offers a route to modify porphyrin properties.
Purpose of the Study:
- To synthesize and evaluate bis-acryl functionalized porphyrins and their metalloporphyrins (M=Co, Mn) for antimicrobial potential.
- To assess the bactericidal efficacy and safety profile of these novel compounds.
Main Methods:
- Synthesis of bis-acryl functionalized porphyrins and their cobalt (Co) and manganese (Mn) complexes.
- Minimum Inhibitory Concentration (MIC) screening against various bacteria.
- Bacteria time-kill kinetic studies to determine killing rates.
- Hemotoxicity and cytotoxicity assays to evaluate safety.
Main Results:
- Several synthesized porphyrins and metalloporphyrins exhibited antimicrobial activity.
- Mn(III) 4-(bis)methylphenyl-substituted-porphyrins demonstrated superior bactericidal effects.
- These Mn(III) compounds were effective even in the dark.
- The active Mn(III) porphyrins showed low hemotoxicity and a favorable cytotoxicity profile.
Conclusions:
- Bis-acryl functionalized manganese porphyrins represent a promising class of antimicrobial agents.
- The observed efficacy in the dark suggests potential for photodynamic therapy-independent applications.
- Further investigation into these compounds could lead to new therapeutic strategies against bacterial infections.
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