Floating-Harbor Syndrome: A Rare Case Report

Area of Science:

• Pediatric Dentistry
• Clinical Genetics
• Rare Diseases

Background:

• Floating-Harbor syndrome (FHS) is an extremely rare genetic disorder characterized by short stature, speech delay, and distinctive facial features.
• FHS affects both sexes, with approximately 50 cases reported in the literature, often leading to delayed diagnosis due to unfamiliarity with its features.
• The syndrome presents with a triad of symptoms, including characteristic facial dysmorphia, making early identification challenging.

Observation:

• A 5-year-old male patient presented with severe dental caries in both deciduous and permanent teeth.
• Clinical examination revealed features consistent with Floating-Harbor syndrome.
• The patient exhibited typical FHS characteristics alongside significant dental abnormalities.

Findings:

• The case highlights the co-occurrence of Floating-Harbor syndrome and extensive dental caries in a pediatric patient.
• Dental abnormalities are a significant manifestation in individuals with FHS.
• This report emphasizes the need for comprehensive dental evaluation in children diagnosed with FHS.

Implications:

• Early diagnosis of FHS is critical for timely intervention and management of associated health issues.
• A multidisciplinary approach involving geneticists, pediatricians, and dentists is essential for optimal patient care.
• Management of FHS is symptomatic and supportive, underscoring the importance of addressing all affected systems, including oral health.