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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

Updated: Nov 16, 2025

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Visual evoked potentials changes with surgery in primary congenital glaucoma: a pilot study.

Mai AbdelNabi Mohamed ElBahwash1, Mahmoud Hassan Morsy1, Amira Saad Mahmoud Hegazy2

  • 1Ophthalmology Department, Faculty of Medicine, Alexandria University, 311 Horeya Avenue, Alexandria, Egypt.

International Ophthalmology
|February 26, 2021
PubMed
Summary

Intraocular pressure (IOP) elevation in primary congenital glaucoma (PCG) impacts optic nerve function. However, successful surgery to control IOP shows no permanent detrimental effect on optic nerve function, evidenced by improved visual evoked potential (VEP) parameters in children.

Keywords:
ElectrophysiologyIntraocular pressureOptic nervePrimary congenital glaucomaVisual evoked potentials

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Area of Science:

  • Ophthalmology
  • Pediatric Ophthalmology
  • Neuroscience

Background:

  • Primary congenital glaucoma (PCG) is a severe form of glaucoma presenting in infancy.
  • Elevated intraocular pressure (IOP) in PCG can lead to optic nerve damage.
  • Visual evoked potentials (VEPs) are electrophysiological tests that assess the function of the visual pathway.

Purpose of the Study:

  • To evaluate flash visual evoked potential (VEP) findings in children with primary congenital glaucoma (PCG).
  • To compare VEP parameters before and after surgical control of intraocular pressure (IOP) in PCG patients.

Main Methods:

  • Children with PCG underwent flash VEP testing before and after surgery.
  • Intraocular pressure (IOP) was measured before and after surgical intervention.
  • VEP parameters, including implicit times and amplitudes of specific waves (N1-P1, N2-P2, P2), were analyzed.

Main Results:

  • A significant reduction in IOP was observed postoperatively (23.0 ± 6.7 mmHg to 8.3 ± 2.4 mmHg, p < 0.0001).
  • There were statistically insignificant changes in P2 implicit time, N1-P1 amplitude, and N2-P2 amplitude postoperatively.
  • The study included 11 eyes of 8 children, with a mean age of 3.5 months at presentation.

Conclusions:

  • Elevated IOP in PCG adversely affects optic nerve function.
  • Successful surgical control of IOP in PCG does not appear to cause permanent detrimental effects on optic nerve function in the short term.
  • Improvements in VEP parameters suggest a reversible impact of IOP on optic nerve function in PCG.