Nerve Growth Factor as an Ocular Therapy: Applications, Challenges, and Future Directions

Area of Science:

• Neuroscience
• Ophthalmology
• Regenerative Medicine

Background:

• Nerve growth factor (NGF) is a key neurotrophin discovered in the 1950s.
• Recent orphan drug status has spurred accelerated research and development in NGF therapies.
• NGF promotes neuronal health and regeneration across various tissues.

Purpose of the Study:

• To review preclinical and clinical evidence for NGF applications.
• To focus on ophthalmic uses, including neurotrophic keratitis, retinal diseases, and glaucoma.
• To discuss the evolving therapeutic profile, challenges, and future directions of NGF therapy.

Main Methods:

• Literature review of preclinical studies.
• Analysis of clinical trial data.
• Examination of FDA-approved indications and ongoing research.

Main Results:

• NGF demonstrates efficacy in promoting neuronal health and regeneration.
• Ophthalmic applications, including FDA-approved neurotrophic keratitis treatment, show significant potential.
• Ongoing research explores NGF for retinal diseases and glaucoma.

Conclusions:

• Nerve growth factor (NGF) is a promising therapeutic agent with an expanding role.
• Further research is needed to address challenges and optimize NGF delivery and efficacy.
• NGF holds potential for treating a range of neurological and ophthalmic conditions.