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Updated: Nov 15, 2025
08:39
Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
Published on: August 25, 2018
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Vaping-associated esophagitis
Trisha Satya Pasricha1, Bharati Kochar2,3
1Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School Boston, 55 Fruit Street, Boston, MA, 02114, USA. tpasricha@mgh.harvard.edu.
BMC Gastroenterology
|March 5, 2021
Summary
Vaping may cause severe esophagitis, a serious gastrointestinal complication. Clinicians should inquire about vaping history, as nicotine may be the cause, similar to smoking.
Area of Science:
- Gastroenterology
- Toxicology
- Public Health
Background:
- Vaping (e-cigarettes) is increasingly popular globally, with 41 million users.
- Unlike tobacco smoking, the gastrointestinal effects of vaping remain largely unknown.
- This study details a novel case of severe esophagitis linked to vaping.
Observation:
- A 25-year-old male with GERD developed severe odynophagia after two months of heavy vaping (nicotine and THC).
- Endoscopy revealed Los Angeles Grade C esophagitis; biopsies showed inflammation and granulation tissue.
- Other causes like infections and eosinophilic esophagitis were ruled out.
Findings:
- Vaping, particularly with nicotine, can lead to severe esophageal inflammation (esophagitis).
- The patient's symptoms resolved completely after vaping cessation and PPI treatment.
- Histopathology confirmed severe esophageal injury without infectious or allergic etiology.
Implications:
- Vaping poses significant gastrointestinal risks, potentially similar to smoking due to nicotine.
- Clinicians must actively ask about vaping history, as patients may not identify it as "smoking."
- Further research is crucial to understand the long-term gastrointestinal consequences of vaping.
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