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Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
Published on: January 24, 2025
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Nanogels Capable of Triggered Release.
Viktor Korzhikov-Vlakh1, Tatiana Tennikova2
1Laboratory of Biomedical Chemistry, Institute of Chemistry, St Petersburg University, St Petersburg, Russia. v.korzhikov-vlakh@spbu.ru.
Advances in Biochemical Engineering/Biotechnology
|March 5, 2021
Summary
Nanogels offer promising drug delivery solutions with their biocompatibility and controlled release capabilities. Sensitive nanogels enable triggered drug release for specific medical treatments like cancer chemotherapy.
Area of Science:
- Polymer Science
- Biomaterials Science
- Nanotechnology
Background:
- Nanogels are soft, environmentally sensitive polymeric nanosystems.
- They exhibit high biocompatibility with biological fluids and tissues.
- Traditional drug delivery systems focus on sustained release, which is not always optimal.
Purpose of the Study:
- To provide an overview of nanogels for drug delivery.
- To discuss the concept and mechanisms of triggered drug release from nanogels.
- To highlight the advantages of nanogels in specific therapeutic applications.
Main Methods:
- Overview of nanogel preparation techniques.
- Discussion of stimuli-responsive properties of nanogels.
- Analysis of triggered release mechanisms for drugs and biomacromolecules.
Main Results:
- Nanogels can be designed for controlled and triggered drug release.
- Environmental sensitivity allows for rapid drug release upon specific stimuli.
- This approach is beneficial for treatments requiring rapid drug concentration increases.
Conclusions:
- Nanogels represent a versatile platform for advanced drug delivery.
- Triggered release from nanogels offers advantages over sustained release for certain therapies.
- Further research into nanogel preparation and release mechanisms is warranted.
