Quantitative Evaluation of Burn Injuries Based on Electrical Impedance Spectroscopy of Blood with a Seven-Parameter...

A quantitative and rapid burn injury detection method has been proposed based on the electrical impedance spectroscopy (EIS) of blood with a seven-parameter equivalent circuit. The degree of burn injury is estimated from the electrical impedance characteristics of blood with different volume proportions of red blood cells (RBCs) and heated red blood cells (HRBCs). A quantitative relationship between the volume portion H_HCT of HRBCs and the electrical impedance characteristics of blood has been demonstrated. A seven -parameter equivalent circuit is employed to quantify the relationship from the perspective of electricity. Additionally, the traditional Hanai equation has been modified to verify the experimental results. Results show that the imaginary part of impedance Z_Imt under the characteristic frequency (f_c) has a linear relationship with H_HCT which could be described by Z_Imt = -2.56H_HCT - 2.01 with a correlation coefficient of 0.96. Moreover, the relationship between the plasma resistance R_p and H_HCT is obtained as R_p = -7.2H_HCT + 3.91 with a correlation coefficient of 0.96 from the seven -parameter equivalent circuit. This study shows the feasibility of EIS in the quantitative detection of burn injury by the quantitative parameters Z_Imt and R_p, which might be meaningful for the follow-up clinical treatment for burn injury.