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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
SARS-CoV-2 infection with pneumonia and encephalitis
Muhammad Hassan1, Fibhaa Syed2, Haris Majid Rajput1
1Department of Neurology, Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan.
This case study highlights a fatal COVID-19 infection with severe respiratory complications. Neurological manifestations in SARS-CoV-2 patients require further investigation due to limited data.
Area of Science:
- Neurology
- Infectious Diseases
- Critical Care Medicine
Background:
- The severe acute respiratory virus (SARS-CoV-2) pandemic primarily presents with respiratory symptoms, including pneumonia and acute respiratory distress syndrome (ARDS).
- Limited data exists regarding the specific neurological manifestations associated with COVID-19 infections.
- Previous studies indicate that less than 30% of the population reported neurological symptoms like headache and delirium.
Observation:
- This case study focuses on a patient diagnosed with COVID-19.
- The patient experienced severe respiratory complications during hospitalization.
- The patient ultimately succumbed to the illness.
Findings:
- The neurotropism of SARS-CoV-2 remains a subject of debate and uncertainty.
- This case underscores the potential for severe outcomes in COVID-19 patients.
Implications:
- Further research is crucial to understand the neurological impact of SARS-CoV-2.
- Investigating COVID-19's neurotropism is essential for comprehensive patient management.
- This case highlights the critical need for vigilance regarding severe COVID-19 presentations.
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