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Related Concept Videos

Properties of Organometallic Compounds01:23

Properties of Organometallic Compounds

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Organometallic compounds are compounds that contain a carbon–metal bond. Carbon belongs to an organyl group like alkyl, aryl, allyl, or benzyl groups. The metal can be from Group I or Group II of the periodic table, a transition metal, or a semimetal.
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Metal-Ligand Bonds02:51

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The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
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Related Experiment Video

Updated: Nov 14, 2025

Author Spotlight: Advances in Evaluating Human Lung Epithelial Cells' Response to Metal-Organic Frameworks
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Antitumor Agents Based on Metal-Organic Frameworks.

Peng Gao1, Yuanyuan Chen1, Wei Pan1

  • 1College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Centre of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan, 250014, P. R. China.

Angewandte Chemie (International Ed. in English)
|March 9, 2021
PubMed
Summary
This summary is machine-generated.

Metal-organic frameworks (MOFs) show promise in medicine, acting as drug carriers, direct antitumor agents, and templates for novel cancer therapies. Their development is rapidly advancing the field of MOF-based antitumor drugs.

Keywords:
antitumor agentscombined therapydrug carriersmetal-organic frameworkssmart drugs

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Synthesis and Characterization of Functionalized Metal-organic Frameworks
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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Metal-organic frameworks (MOFs) possess unique porous structures and tunable compositions.
  • These properties make MOFs highly suitable for various biomedical applications, particularly in cancer treatment.
  • The past two decades have seen significant advancements in MOF-based drug development for oncology.

Purpose of the Study:

  • To review the design and applications of MOF-based antitumor agents.
  • To cover MOFs as carriers, intrinsic antitumor agents, synergistic systems, and derived agents.
  • To discuss the challenges and future opportunities for clinical translation of MOF-based cancer therapies.

Main Methods:

  • Literature review focusing on MOF design principles for antitumor applications.
  • Categorization of MOF roles in cancer therapy: carriers, active agents, synergistic systems, and precursors.
  • Analysis of existing research and future prospects in MOF-based oncology.

Main Results:

  • MOFs can serve as effective drug delivery vehicles due to their high surface area and porosity.
  • MOFs can be designed with inherent anticancer properties or combined with chemotherapeutics for synergistic effects.
  • MOFs can act as templates for creating novel antitumor agents and MOF-derived nanomaterials.

Conclusions:

  • MOF-based strategies offer diverse and promising avenues for developing advanced antitumor agents.
  • Further research and development are crucial to overcome challenges and realize the clinical potential of MOFs in cancer treatment.
  • The versatility of MOFs positions them as key players in the future of nanomedicine for oncology.