Related Experiment Video
Updated: Jul 25, 2026
11:52
Analysis of Targeted Viral Protein Nanoparticles Delivered to HER2+ Tumors
Published on: June 18, 2013
11.5K
DHA/Fe2+-doped porphyrin COFs enable ROS-amplified multimodal tumor therapy
Qiaoqiao Sun1, Yuanhao Song1, Rongrong Liu2
1College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan, 250014, P. R. China. liyanhua@sdnu.edu.cn.
Chemical Communications (Cambridge, England)
|March 13, 2026
Summary
This study introduces a novel porphyrin-based framework for cancer treatment. It combines reactive oxygen species generation, chemodynamic therapy, and photodynamic therapy to significantly boost antitumor efficacy.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Developing advanced materials for targeted cancer therapy is crucial.
- Existing therapies face challenges like drug resistance and side effects.
- Covalent organic frameworks (COFs) offer tunable properties for biomedical applications.
Purpose of the Study:
- To develop a porphyrin-based covalent organic framework (COF) system doped with Fe2+ and dihydroartemisinin (DHA).
- To investigate the synergistic effects of multiple therapeutic modalities for enhanced antitumor therapy.
- To explore the coordinated generation of reactive oxygen species (ROS) for amplified oxidative stress.
Main Methods:
- Fabrication of a porphyrin-based COF system.
- Doping the COF with Fe2+ and dihydroartemisinin (DHA).
- Evaluation of ROS generation, including DHA-derived radicals, Fe2+-driven chemodynamic therapy (CDT), and porphyrin-mediated photodynamic therapy (PDT).
Main Results:
- The developed platform successfully integrates Fe2+ and DHA within the porphyrin-based COF.
- Coordinated generation of ROS from multiple sources was achieved.
- Significant amplification of oxidative stress was observed, leading to enhanced therapeutic efficacy.
Conclusions:
- The porphyrin-based COF system doped with Fe2+ and DHA represents a promising platform for enhanced antitumor therapy.
- The synergistic combination of CDT and PDT, amplified by ROS generation, offers a potent strategy against cancer.
- This multi-modal approach holds potential for overcoming therapeutic limitations and improving patient outcomes.
Related Concept Videos
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:56Treatment Resistant Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...