Related Experiment Video
Updated: Jul 25, 2026

Analysis of Targeted Viral Protein Nanoparticles Delivered to HER2+ Tumors
Published on: June 18, 2013
DHA/Fe2+-doped porphyrin COFs enable ROS-amplified multimodal tumor therapy
Qiaoqiao Sun1, Yuanhao Song1, Rongrong Liu2
1College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan, 250014, P. R. China. liyanhua@sdnu.edu.cn.
Abstract:
A porphyrin-based covalent organic framework system doped with Fe2+ and dihydroartemisinin (DHA) has been developed for enhanced antitumor therapy. This platform enables coordinated generation of reactive oxygen species (ROS) including DHA-derived radicals, Fe2+-driven chemodynamic therapy (CDT), and porphyrin-mediated photodynamic therapy (PDT), which collectively amplify oxidative stress and significantly improve therapeutic efficacy.
Related Concept Videos
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Treatment Resistant Cancers
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

